1897: Den tyske kjemikeren Felix Hoffmann i firmaet Bayer fremstiller det smertestillende legemiddelet acetylsalisylsyre. Utgangsstoffet salisylsyre hadde imidlertid blitt brukt i årtusener i folkemedisinen i ekstrakter fra blant annet pilbark og seljebark.Det finnes ingen medisiner som fullstendig kurerer revmatiske sykdommer eller kroniske ledd-
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